4. Obesity: The Weighty Issue in Colorectal Cancer
So, the scale’s been tipping a bit more than usual. What’s the big deal, right? Actually, it’s a pretty massive deal when it comes to colorectal cancer. Obesity isn’t just about vanity and beach bodies; it’s a genuine health hazard. Fat cells, especially those around the belly, aren’t inert. They’re biochemical factories producing hormones and inflammatory substances.
The hormones released by fat cells, such as leptin, have been scrutinized under the scientific lens. Leptin not only regulates appetite but also controls cell growth. An overabundance of this hormone can set the stage for abnormal cell growth, a cornerstone for cancer. It’s a complex puzzle, and each piece adds another layer of risk.
Let’s delve into the cytokines released by fat cells. These are proteins that act like messengers between cells. One such cytokine is adiponectin, which has anti-inflammatory properties. Less adiponectin means more inflammation, paving the way for colorectal cancer. It’s like the body’s checks and balances system goes awry.
We can’t talk about obesity without mentioning the liver. The liver produces bile acids to help digest fat. When you’re obese, the liver produces more bile, which gets broken down in the gut into secondary bile acids. These secondary bile acids are potential carcinogens. It’s a vicious cycle that starts with those extra pounds. (4)
