Cause 3. Genetic Predispositions: Inheritance Beyond Traits and Features
When speaking of genetics, one typically imagines eye color, hair type, or perhaps, a propensity for a specific talent. However, genes have a vast influence, often holding the blueprint for our vulnerability to certain conditions. One such example is the connection between specific genes and the onset of SJS.
At the heart of this genetic association lies the HLA gene. Certain variations of this gene, especially prevalent in specific populations, have shown a higher susceptibility to SJS. It’s a silent inheritance, one which individuals may not even be aware of until an external trigger, like a particular medication, activates it.
However, one might wonder, why this particular gene? The HLA gene plays a crucial role in our immune system. It guides the body in differentiating between its own cells and external invaders. When there’s a variation in this gene, this discerning ability might get compromised, possibly leading to autoimmune reactions such as SJS.
But genetics isn’t just about predispositions. There’s a growing field of pharmacogenetics, which delves into how one’s genetic makeup affects drug reactions. Through this, it’s hoped that in the future, medications can be tailored to individuals, reducing adverse effects like SJS. (3)
