2. Jaundice: The Underlying Message Behind the Yellowing
The pancreas and the liver have a symbiotic relationship, often working hand-in-hand to ensure optimal digestion and detoxification. This interdependence is facilitated by the bile duct, which acts as a conduit for digestive enzymes and bile.
The pancreas secretes enzymes that play a pivotal role in breaking down food, while the liver produces bile, which aids in fat digestion. This seamless integration ensures that our body can absorb the nutrients from the food we consume, optimizing our overall health.
Jaundice, characterized by the yellowing of the skin and eyes, isn’t a disease in itself but a symptom. It indicates an elevated level of bilirubin in the bloodstream.
Bilirubin is a waste material that remains in the bloodstream after iron is removed from the blood. Under normal circumstances, the liver filters out this bilirubin, which is then excreted in the stool. However, if there’s a blockage, or the liver is not functioning properly, this bilirubin can accumulate, leading to jaundice.
How does PDAC come into the picture, you ask? As PDAC progresses, the growing tumor can press against or even invade the bile duct, causing a blockage. This obstruction prevents bilirubin from being effectively processed and eliminated from the body. With nowhere to go, bilirubin builds up in the bloodstream, resulting in jaundice.
It’s worth noting that the blockage doesn’t just affect bilirubin removal. A blocked bile duct can also prevent digestive enzymes from reaching the intestines, which further complicates digestion. (2)
