Symptom 5: Changes in Mental State
Changes in mental state can serve as a key indicator of Wernicke-Korsakoff Syndrome. These shifts often come about as apathy or a lack of interest in previously enjoyed activities, offering a noticeable contrast to prior behavior. The individual may display signs of withdrawal, preferring solitude to social activities they once relished. This shift could be gradual, slowly progressing over time, or it might be a sudden change, leaving friends and family baffled and concerned.
In this state of indifference, individuals may exhibit diminished enthusiasm towards hobbies they once pursued with vigor. This lack of motivation is not due to laziness or a change of heart. It is a direct consequence of the neurological changes brought about by WKS. They might cease participation in social events, ignore opportunities for interaction, or exhibit a general lack of interest in maintaining relationships. Loved ones might notice that the individual seems detached, unresponsive, or disinterested in conversation and social bonding.
A critical aspect to understand is that these shifts are not necessarily a sign of depression or a change in personality. Yes, they may mirror symptoms observed in mood disorders, but in the context of other symptoms – particularly in individuals known to have chronic alcohol misuse or malnutrition – these changes could point towards WKS. It’s worth noting that this indifference observed in WKS is not merely a psychological symptom – it stems from the physical alterations in the brain caused by thiamine deficiency. (5)
