Medication 8: Apomorphine: Rapid Relief for “Off” Periods
Apomorphine (Apokyn) is a fast-acting injectable medication used as a rescue therapy for sudden “off” periods experienced by some Parkinson’s patients. “Off” periods are characterized by a sudden return of motor symptoms when the effects of levodopa wear off between doses. Apomorphine works by stimulating dopamine receptors in the brain, providing rapid relief from motor symptoms.
Due to its rapid onset of action, apomorphine is typically reserved for use as needed during “off” periods, rather than as a primary treatment for Parkinson’s disease. It can be particularly helpful for patients who experience unpredictable fluctuations in their response to levodopa.
Apomorphine can cause side effects such as nausea, vomiting, and low blood pressure. Patients taking apomorphine may also be prescribed anti-nausea medications to help manage these side effects. Healthcare providers will closely monitor patients using apomorphine and adjust treatment plans as needed to ensure optimal symptom relief and patient safety. (8)
