Symptom 3: Cardiac Abnormalities – Alagille Syndrome’s Impact on the Heart
Alagille Syndrome doesn’t merely affect the liver; it also leaves an imprint on the heart. Many patients with this condition develop cardiac abnormalities, a term that covers various structural problems with the heart. These irregularities disturb the heart’s rhythm, the symphony that keeps life in motion.
The most common cardiac abnormality seen in Alagille Syndrome is pulmonary stenosis. In this condition, the pulmonary valve, responsible for controlling the blood flow from the heart to the lungs, narrows. This abnormal narrowing hampers the smooth flow of blood, causing the heart to work harder than usual.
In the heart’s chambered halls, rhythm is everything. The synchronization of contractions and relaxations keeps the lifeblood flowing. But pulmonary stenosis, like a discordant note, disturbs this symphony. The heart is forced to work harder, pushing against the increased resistance.
Another common defect is Tetralogy of Fallot, a combination of four heart defects, including a hole in the heart and obstruction of blood flow to the lungs. This combined defect forces the heart to go into overdrive to maintain the circulation, much like a damaged engine pushing to keep a vehicle running.
While these heart defects vary in severity, even the mildest can significantly affect the quality of life. They underscore the fact that Alagille Syndrome isn’t merely a disorder of the liver or bile ducts; it echoes in the heartbeats too. The narrative of cardiac abnormalities in Alagille Syndrome is a tale of rhythm and resistance, a testament to the heart’s resilience amidst adversity. (3)
