3. Progressive Kidney Disease: The Hallmark of Alport Syndrome
As Alport Syndrome progresses, the affected individuals will experience a decline in kidney function, which can eventually lead to chronic kidney disease (CKD) or end-stage renal disease (ESRD). The speed at which the disease progresses can vary significantly among individuals, with some experiencing a rapid decline in kidney function, while others may have a more gradual progression.
Kidney function is typically assessed by measuring the glomerular filtration rate (GFR), which indicates how efficiently the kidneys are filtering waste products from the blood. A decline in GFR is often accompanied by an increase in blood pressure, as the kidneys play a critical role in regulating blood pressure.
As kidney function worsens, additional symptoms may emerge, such as fatigue, swelling, and changes in urine output. Management of progressive kidney disease involves addressing the underlying cause, in this case, Alport Syndrome, and implementing measures to slow down the progression, such as blood pressure control and dietary modifications. (3)
