6. Swelling: A Warning Sign of Worsening Kidney Function
Swelling, or edema, can be another symptom of Alport Syndrome, particularly as kidney function declines. Edema occurs when fluid builds up in the body’s tissues.
In the case of Alport Syndrome, the decline in kidney function means that the kidneys are unable to properly filter waste and excess fluid from the body, leading to fluid accumulation in the tissues. This fluid accumulation can result in swelling in various parts of the body, including the face, legs, ankles, and feet.
In some cases, edema may be accompanied by high blood pressure, which can also be a symptom of Alport Syndrome as the kidneys are unable to regulate blood pressure effectively. Additionally, as the kidneys become damaged, they may produce less of a hormone called erythropoietin, which is responsible for stimulating the production of red blood cells. A decrease in erythropoietin levels can result in anemia, which can cause fatigue, weakness, and shortness of breath.
It’s important for individuals with Alport Syndrome to receive regular check-ups and monitoring from a nephrologist, or kidney specialist. In advanced cases of Alport Syndrome, a kidney transplant may be necessary to replace the damaged kidneys with a functioning donor kidney. In some cases, dialysis may also be necessary to remove waste and excess fluid from the body.
Managing swelling in individuals with Alport Syndrome may involve addressing the underlying kidney dysfunction, as well as implementing measures to alleviate fluid buildup, such as elevation of the affected limbs, compression stockings, and diuretic medications. (6)
