2. Basophils and Their Role in Inflammatory Diseases
Basophils are deeply involved in inflammatory processes. They are often elevated in diseases characterized by chronic inflammation, such as rheumatoid arthritis.
In these diseases, basophils release substances that exacerbate inflammation. This contributes to the symptoms experienced by patients, like joint pain and swelling.
The relationship between basophils and inflammation is complex. These cells release cytokines, which are signaling proteins that promote inflammation.
This release can be a response to various stimuli, including infections and autoimmune reactions. Cytokines from basophils help coordinate the body’s defense, but they also play a role in the persistence of inflammation in certain conditions.
In autoimmune diseases, the body’s immune system mistakenly attacks its own tissues. Basophils are implicated in this process. They may contribute to the misguided immune response seen in conditions like lupus.
Research is ongoing to understand how basophils can be regulated in such diseases. The aim is to reduce harmful inflammation while preserving necessary immune functions.
Targeting basophils has become a focus in treating inflammatory diseases. By modulating their activity, it may be possible to alleviate symptoms of chronic inflammation.
Biologic drugs, which target specific parts of the immune system, are being explored in this context. These treatments hold the promise of reducing the adverse effects of inflammation while maintaining immune competence. (2)
