Fact 4. The Invisible Culprit: Alpha-Synuclein
One cannot discuss MSA without bringing up alpha-synuclein, an abundant protein in the brain that’s intimately connected with MSA’s progression. Alpha-synuclein under normal circumstances plays a host of crucial roles in maintaining neuronal health. It aids in the smooth communication between neurons and contributes to the overall function of the brain.
However, in conditions like MSA, alpha-synuclein seems to go rogue. It forms abnormal protein deposits within the brain cells, an event that isn’t part of its regular behavior. These protein aggregates, known in the medical world as glial cytoplasmic inclusions (GCIs), have become an identifying marker for MSA, aiding in its diagnosis.
To put it in perspective, imagine a well-behaved member of a community suddenly becoming unruly and causing disruption. The once peaceful neighborhood, in this case, the brain cells, are now under stress due to this abnormal behavior. In the same way, the formation of GCIs disrupts the normal functioning of brain cells, leading to the progressive damage we see in MSA.
The puzzle of why alpha-synuclein behaves the way it does in MSA is yet to be solved. Numerous researchers are pouring over this mystery, trying to understand the triggers behind this abnormal behavior. While the exact reasons remain unknown as of now, the link between alpha-synuclein and MSA is undeniable. (4)
