Symptom 9: Flattening or Inversion of the Nipple
Nipple changes, such as flattening or inversion, are yet another symptom often associated with Paget’s disease. A healthy nipple typically protrudes outward, but in cases of Paget’s disease, the nipple might appear unusually flat or even inverted. It’s essential to note that these changes are generally new developments, not characteristics that have been present since birth.
These alterations can occur due to the underlying changes in breast tissue, as cancer cells disrupt the natural architecture. The cells may cause fibrosis or scarring, leading to a pull on the nipple tissue and resulting in its flattening or inversion. This symptom, while not exclusive to Paget’s disease, raises a red flag and requires medical attention.
Not all individuals experiencing this symptom may notice it right away. Often, the changes are subtle initially and may be overlooked. However, with time, the alterations become more apparent, prompting a need for evaluation. Some individuals may even notice these changes during their routine breast self-examination.
When nipple changes are observed, it’s crucial to consult a healthcare provider promptly. They will likely perform a clinical examination and recommend imaging studies, like a mammogram or an ultrasound, to understand the underlying cause better. Biopsy might also be warranted in some cases to identify the presence of Paget’s disease. (9)
