Fact 5: Genetics Play a Role in Papillary Thyroid Cancer
Genetics also contribute significantly to the risk profile of PTC. Specific genetic mutations have been identified in association with this form of cancer. Mutations in the BRAF and RAS genes, among others, have been implicated in the pathogenesis of PTC. Also, some forms of PTC are associated with rearrangements of the RET gene, known as RET/PTC rearrangements.
Familial clustering of PTC cases also points to a genetic element. This means if you have a first-degree relative, such as a parent, sibling, or child with PTC, your risk of developing the disease is higher. However, most PTC cases are sporadic, meaning they occur in people without a family history of the disease.
Understanding the genetic basis of PTC has greatly contributed to advancements in treatment approaches. For instance, targeted therapies that specifically inhibit the action of mutated genes have shown promise in treating PTC. These genetic insights continue to shape the future of PTC diagnosis and treatment. (5)
