Cause 6: Gut Permeability: When the Barrier Breaks Down
When exploring the causes of ulcerative colitis, we cannot overlook the importance of gut permeability, often referred to as the integrity of the gut barrier. This barrier, a lining of the intestines, acts as a fortress that prevents harmful substances from entering the bloodstream.
In UC, this defensive wall is compromised. It’s akin to the fortress walls developing cracks, allowing enemy forces – harmful substances from the gut – to infiltrate. This phenomenon, often referred to as ‘leaky gut,’ triggers an immune response leading to inflammation, a hallmark of UC.
What causes this increased gut permeability? Various factors come into play. Genetic predisposition can make an individual’s gut barrier more susceptible to damage. Dysbiosis of the gut microbiome, where the balance of healthy and harmful bacteria in the gut is disturbed, can also lead to a leaky gut.
Moreover, exposure to certain medications and dietary components can also compromise the gut barrier. For instance, frequent use of NSAIDs and a diet high in processed foods can negatively affect the integrity of the gut barrier. (6)
