Fact 5: The Genetic Connection in Pick’s Disease
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While most cases of Pick’s disease occur sporadically, about 10% to 20% of cases have a genetic link. They are caused by mutations in specific genes, including the MAPT gene, which codes for the tau protein.
A familial pattern of Pick’s disease means that if a parent has the disease, there is a 50% chance that they could pass the mutation to their offspring. This pattern of inheritance, known as autosomal dominant, can lead to multiple cases within a single family.
Genetic testing and counseling play vital roles in cases of familial Pick’s disease. Identifying a mutation can confirm the diagnosis and provide valuable information for other family members who may be at risk. (5)
