Fact 7: Zooming in on ICP – A Special Case of Cholestasis During Pregnancy
Intrahepatic Cholestasis of Pregnancy (ICP) represents a unique and critical subset of cholestasis, occurring specifically in pregnant women. This condition not only causes discomfort due to intense itching but also carries significant risks for both the mother and the unborn child.
ICP typically manifests in the third trimester of pregnancy and is characterized by the impairment of bile flow within the liver. The resulting buildup of bile acids in the bloodstream leads to intense itching, particularly on the palms of the hands and soles of the feet, though it can spread to other parts of the body.
The risks associated with ICP are profound. The condition has been linked to an increased risk of preterm birth, fetal distress, and in severe cases, stillbirth. As such, early diagnosis and careful management are imperative to safeguard the health of both mother and baby.
Management of ICP often involves medications to alleviate symptoms and reduce bile acid levels, alongside vigilant monitoring of the baby’s wellbeing. In many cases, early delivery is considered around 37 weeks of pregnancy to mitigate the risks associated with ICP.
Addressing ICP is a critical component of prenatal care, emphasizing the need for awareness, prompt diagnosis, and meticulous management. By taking these steps, healthcare providers can help ensure the best possible outcomes for both mother and child, navigating the challenges of ICP with precision and care. (7)
