12. Inherited Nature of PTEN Gene Mutations
In the twelfth fact, we delve into the inherited nature of PTEN gene mutations. Most mutations in the PTEN gene are passed down from parents to their children, following an autosomal dominant inheritance pattern.
In this type of inheritance, an individual needs to inherit only one copy of the mutated gene from one parent to have the mutation. Each child of an individual with a PTEN gene mutation has a 50% chance of inheriting the mutation.
It’s important to note that even if a child inherits the PTEN gene mutation, the type and severity of symptoms can vary. This variation, often referred to as variable expressivity, can be influenced by several factors, including other genetic and environmental influences.
By understanding the inheritance pattern of PTEN gene mutations, healthcare providers and affected families can make more informed decisions regarding family planning and potential genetic counseling. It can also be instrumental in developing personalized surveillance plans for those at risk. (12)
