9. Variants of PTEN Gene Mutations
As we venture into fact number nine, we uncover the complexity of PTEN gene mutations. Not all mutations in this gene are the same. These mutations can vary based on the specific change in the DNA sequence and the resultant effect on the protein that the gene codes for.
For instance, some PTEN gene mutations may result in a protein that is unstable or less functional. Other mutations might create a protein that is entirely non-functional. Still, other mutations might lead to the production of an abnormally short protein, or in some cases, prevent the production of any protein at all.
These variations significantly impact the severity of the associated conditions. For instance, mutations that result in a less functional PTEN protein might be associated with milder symptoms, while mutations that prevent any protein production might lead to more severe manifestations. (9)
