Cause 3. Gastrointestinal Issues: The Unseen Impact
Gastrointestinal issues can play a significant role in the development of pernicious anemia. Certain conditions affecting the digestive system, such as Crohn’s disease, celiac disease, or atrophic gastritis, can hinder the absorption of vital nutrients like vitamin B12. This impaired absorption can lead to a deficiency and, ultimately, pernicious anemia.
Crohn’s disease, for instance, is a chronic inflammatory bowel disease that can affect any part of the gastrointestinal tract. This inflammation can damage the lining of the intestine, leading to malabsorption of nutrients, including vitamin B12. Similarly, celiac disease is an autoimmune disorder in which the ingestion of gluten leads to damage in the small intestine. This damage can impair the body’s ability to absorb nutrients effectively.
In the case of atrophic gastritis, the stomach lining becomes inflamed and starts to waste away, leading to a decreased production of stomach acid and intrinsic factor. As mentioned earlier, intrinsic factor is crucial for vitamin B12 absorption, and its absence can result in pernicious anemia.
Treatment for pernicious anemia related to gastrointestinal issues typically involves addressing the underlying condition, which may include dietary modifications, medications, or other interventions. Additionally, vitamin B12 supplementation may be necessary to ensure proper red blood cell production. (3)
